The effects of levocitirize dihydrochloride on serum IL-13 and IL-18 in patients with cough variant asthma

VernacularTitle:左旋西替利嗪对咳嗽变异性哮喘患者血清白细胞介素13与白细胞介素18的影响
Author: Mingsheng LI ; Ya LIU ; Xiaolu ZHENG ; Jifu LI ; Liya SHI ; Shuangyin CAO ; Mingyou LU
Publication Type:Journal Article
Keywords: Cough variant asthma; Levocitirize dihydrochloride; Interleukin-13; Interleukin-18
From: Chinese Journal of Primary Medicine and Pharmacy 2009;16(3):445-446
CountryChina
Language:Chinese
Abstract: Objective To explore the effects of Levoeitirize dihydrochloride on interleukin-13(IL-13)and interleukin-18(IL-18)in the serum of the patients with cough variant asthma(CVA).Methods 70 cases with CVA were randomly devided into control group of 35 cases and treatment group of 35 cases.Control group was given Chlort rimeton and the treatment group was given Levocitirize dihydroehloride.The levels of IL-13 and IL-18 in the serum were measured before and after treatment.Results After treatment,the concentrations of IL-13 and IL-18 in patients in the treatment group were(46.7±17.3)ng/L and(145.2±27.1)ng/L，and those in the control group were(98.5±30.7)ng/L and(179.6±30.5)ne/L，which were significantly improved.Conclusion The treatmem of Levoeitirize dihydrochloride could improve the CVA through improving the production of IL-13 and IL-18.