Primary cutaneous aggressive epidermotropie CD8-positive cytotoxic T-cell lymphoma:a case report

VernacularTitle:皮肤原发性侵袭性亲表皮CD8阳性细胞毒性T细胞淋巴瘤一例
Author: Yang WANG ; Lin NONG ; Lingshen WU ; Ting LI ; Ping TU
Publication Type:Journal Article
Keywords: Lymphoma,T-cell,cutaneous; T-lymphocytes,cytotoxic
From: Chinese Journal of Dermatology 2009;42(4):237-240
CountryChina
Language:Chinese
Abstract: A 19-year-old Chinese woman presented with progressive ulcers and recurrent fever for 1 year.The lesions originally began with purplish red maculopapules,then rapidly developed into ulcer with severe pain and spread to the trunk and extremities accompanied by intermittent fever.Histopathology revealed lymphoid infiltration of middle and large atypical T cells throughout the dermis and subcutaneous fat laver along with focal epidermotropism.The lymphoid infiltrates were positive for CD3,CD8,T-cell intercellular antigen(TLA)and T-cell receptor β(TCR-β).Gene analysis showed the rearrangement of T-cell receptor gene.According to the above findings,the patient was diagnosed as primary cutaneous aggressive epidermotropic CD8-positive cytotoxic T-cell lymphoma. Combined thempy with cyclophosphamide,vincristine,prednisone and bleomycin resulted in partial remission of skin lesions,but she eventually died 22 months after the onset of disease.