Prognosis of patients with gastrointestinal stromal tumors
10.3760/cma.j.issn.1007-631X.2009.04.001
- VernacularTitle:胃肠道间质瘤预后因素分析
- Author:
Xiaodong SHEN
;
Xun GONG
;
Jianbin XIANG
;
Peng SUN
;
Zongyou CHEN
- Publication Type:Journal Article
- Keywords:
Gastrointestinal stromal tumors;
Pathology,clinical;
Prognosis
- From:
Chinese Journal of General Surgery
2009;24(4):265-268
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the prognostic factors of gastrointestinal stromal tumors.Methods From Nov.1999 to Dec.2006,a total of 85 patients were diagnosed by postoperative pathology as gastrointestinal stromal tumors.The relationship between the prognosis of GIST and demographic factors、tumor location、operation style、preoperative metastasis、lymphadenectomy、grading of Fletcher were analyzed retrospectively.Results The 1 year、3 year and 5 year survival rate of these 85 patients were 94%,60%,57%respectively,Univariate analysis indicated that tumor location、operation style、grading of Fletcher and preoperative metastasis were significant predictors of survival(P<0.05),while demographics and lymphadenectomy were not statistically related with prognosis.Multivariate analysis showed that preoperative metastasis was the independent factor predicting the prognosis(P=0.020,β=4.226).Conclusion Radical surgical excision is still the therapy of choice for primary gastrointestinal stromal tumors.Preoperative metastasis is the independent factor predicting poor prognosis,therefore early diagnosis and treatment are very important for GIST.Fletcher grading is also a simple recalls to predict the prognosis of GIST.
