Relationship between TGF-betal and BRCA2 expression and clinical related factors in breast cancer
- VernacularTitle:乳腺癌TGF-β1和BRCA2表达与临床因素相关性研究
- Author:
Junchuan LI
;
Hongyu ZHU
;
Tingxuan CHEN
;
Guihua DAI
;
Lanying ZOU
;
Huichuan ZHAO
- Publication Type:Journal Article
- Keywords:
Breast neoplasms/GE;
Transforming growth factor beta;
Genes,BRCA2;
Prognosis
- From:
Journal of Chinese Physician
2009;11(3):344-346
- CountryChina
- Language:Chinese
-
Abstract:
Objective To explore the relationship between TGF-beta1,BRCA2,HER2,ER,PR and clinical factors in breast cancer.Methods The expression of TGF-beta1,BRCA2,HEB2,ER,PB in 67 cases breast carcinoma were detected by immunohistochemistry staining SP method.The correlation of the results with other parameters which included age,pathohistological grade,status of auxiliary lymph nodes were analyzed by mono-factor unconditional logistic regression analysis.Results The expression of TGF-beta1 was correlated with BRCA2.and the expression of BRCA2 was correlated with TGF-beta1 and c-erbB-2 in breast cancer.Condusion Overexpression of BRCA2 was related with TGF-beta1 and HER2 in breast carcinoma.It was useful in breast carcinoma prognosis by detecting these three factors.
