Matrix metalloproteinase-9 level and its clinical significance in patients with progressive ischemic stroke
10.3760/cma.j.issn.1008-6315.2009.04.016
- VernacularTitle:进展性缺血性卒中患者血清基质金属蛋白酶-9水平及其临床意义
- Author:
Weixiang ZHU
;
Dali WANG
;
Li ZHANG
;
Yanbo PENG
- Publication Type:Journal Article
- Keywords:
Progressive ischemic stroke;
Matric metalloproteinase-9
- From:
Clinical Medicine of China
2009;25(4):378-380
- CountryChina
- Language:Chinese
-
Abstract:
Objective To study the level changes of matrix metalloproteinase-9 (MMP-9)and its clinical significance in patients with progressive ischemic stroke(PIS).Methods 136 cases of acute ischemic stroke including 46 cases of PIS and 90 cases of non-PIS,were studied.56 healthy subjects were selected into control group.MMP-9 level was measured by ELISA at 2,7 and 14 day after admission.The neurologic dysfunction score was observed.Results The MMP-9 level was ( 249.43 ± 63.76)μg/L,( 271.50±72.08 )μg/L,and (183.20 ±66.69)μg/L in PIS group,while it was (158.81±49.18 )μg/L,( 188.67±57.96 )μg/L,and ( 93.86 ±22.16)μg/L in non PIS group and was (88.60±15.93 )μg/L in control group at 2,7 and 14 days of admission.The MMP-9 level of PIS group at 2,7 and 14 day and the level in non PIS group at 2 and 7 day were higher than that of control group(P＜0.01 ).The MMP-9 level of PIS group was higher than that of different phrase of PIS group (P＜0.01 ).Linear X2 showed that the increase of MMP-9 level would increase the risk of ischemic stroke progression( X2=38.96,P＜0.01 ).Conclusion The remarkable increase of MMP-9 in patients with progressive ischemic stroke may be the indepent risk factor of the progression of ischemic stroke.
