Role of low-molecule-weight heparin in cancer metastasis
10.3760/cma.j.issn.1673-4203.2009.04.014
- VernacularTitle:低分子肝素抑制肿瘤转移的研究进展
- Author:
Yijia LIN
;
Jianbo XU
;
Changhua ZHANG
- Publication Type:Journal Article
- Keywords:
low-molecule-weight heparin;
cancer metastasis;
heparinase;
selectin;
angiogenesis
- From:
International Journal of Surgery
2009;36(4):253-255
- CountryChina
- Language:Chinese
-
Abstract:
Cancer metastasis is multi-step process that requires cancer cells to jump through many hoops.The low-molecule-weight beparin (LMWH) has been reported effective for the treatment of metastasis to some extent, the mechanisms are proposed as anticoagulation, inhibition of heparanase, selectins, adhesion, angiogenesis mediated by the tumor cells, and the effects on cell cycle and apoptosis.
