Application of anti-infective reconstituted bone xenograft in one-stage treatment of adult posttrau matic osteomyelitis
10.3760/cma.j.issn.1001-8050.2009.04.102
- VernacularTitle:抗感染活性骨在成人创伤性骨髓炎治疗中的应用
- Author:
Zhi YUAN
;
Jian LIU
;
Yunyu HU
;
Jianmin LIU
;
Ming LIU
;
Guolin MENG
;
Peng YANG
;
Jiakai GAO
- Publication Type:Journal Article
- Keywords:
Osteomyelitis;
Bone transplantation;
Bone morphogenetic protein;
Gentamicins
- From:
Chinese Journal of Trauma
2009;25(4):333-337
- CountryChina
- Language:Chinese
-
Abstract:
Objective To validate the effect of anti-infective reconstituted bone xenograft (ARBX) in treating posttraumatic osteomyelitis by one-stage grafting in the adults.Methods With clinical application approval of Medical Command,Logistics Ministry of PLA,ARBX was used to treat 27 adult patients (29 lesions) with posttraumatic osteomyelitis by one-stage grafting after debridement since September 2001.The study analyzed 27 patients (29 grafts) who were followed up for average 26 months (12-63 months).Results The follow-up for average 26 months (12-63 months) in 27 patients showed that infection of 22 patients (24 lesions) was controlled and cured,except for three with failure to control the infection or with recurrence of infection,two with controlled infection but with postoperative nonunion.The infection control rate was 89.7% (26/29) and the cure rate was 82.8% (24/29) ,which were better than the results of traditional therapy.Conclusions ARBX has high osteoinductive activity and enhanced anti-infective capability,which enables it to be used as one-stage grafting to treat posttraumatic osteomyelitis in the adults.
