Expression and clinical significance of IL-6 and IL-6 receptor in hysteromyoma

VernacularTitle:白细胞介素-6及其受体在子宫肌瘤的表达及意义
Author: Cairong LI ; Dingqing FENG ; Ying ZHOU ; Bin LING
Publication Type:Journal Article
Keywords: Hysteromyoma; IL-6; IL-6 recptor
From:Clinical Medicine of China 2009;25(4):360-362
CountryChina
Language:Chinese
Abstract: Objective To investigate the expression and significance of IL-6 and IL-6 receptor (IL-6R)in hysteromyoma.Methods The expression of IL-6 in hysteromyoma and homologous normal myometrium of 20 cases undergoing total hysterectomy were detected by fluorescent quantitative PCR and western-blot,respectively while IL6R was examined by western-blot and RT-PCR.Results The expression of IL-6 protein and mRNA in homologous normal myometrium were obviously higher than that in hysteromyoma[(0.7996 ±0.0359)vs (0.6904 ±0.0414)and (0.0470±0.0071)vs(0.0283±0.0045 ),P＜0.05] ;No difference was observed in IL-6R protein and mRNA expression between leiomyomas and myometrium[(0.7105 ±0.0520)vs (0.6904 ±0.0532)and (0.6644 ±0.0537 )vs (0.6465±0.0501),P＞0.05 ].Conclusion The lower expression of IL-6 in leiomyomas may contribute to the pathogenesis of hysteromyoma to some extent,and there is no relationship between IL-6R and hysteromyoma.