Effect of levetiracetam on electrocorticogram of epileptic rats induced by lithium-pilocarpine
- VernacularTitle:左乙拉西坦对氯化锂-匹鲁卡品致癫癎大鼠模型皮层脑电图的影响
- Author:
Jing WU
;
Songqing PAN
- Publication Type:Journal Article
- Keywords:
Piracetam/AA/PD;
Epilepsy/DT/PP;
Lithium chloride/AE;
Pilocarpine/AE;
Electroencephalography
- From:
Journal of Chinese Physician
2009;11(3):312-314
- CountryChina
- Language:Chinese
-
Abstract:
Objective To explore the effect of Levetiracetam on Electrocorticogram of epileptic rats induced by lithium-Pilocarpine.Methods Sixteen SD rats were randomly divided into two groups(8 rats in each group),normal saline group and Levetiracetam group.After epileptic model was induced by lithium-Pilocarpine,lateral ventricle was administered with Levetiraeetam and saline by the same volume.The change of frequency of epileptic discharge and different brainwave proportion distribution was observed.Results Compared with normal saline group,the epileptic discharge were significantly decreased(P＜0.01)and the proportion of δ wave was enhanced,meanwhile β wave was decreased in Levetiraeetam group(P＜0.05).Conclusion Levetiracetam has the role of anti-epilepsy in acute model of epileptic rats induced by lithium-Pilocarpine.
