Research progress on mechanism and premedication regimen of taxanes hypersensitivity reactions
10.3760/cma.j.issn.1673-422X.2009.03.010
- VernacularTitle:紫杉类药物过敏反应发生机制及预处理方案
- Author:
Mingjun ZHANG
;
Zhendong CHEN
- Publication Type:Journal Article
- Keywords:
Taxoids;
Anaphylaxis
- From:
Journal of International Oncology
2009;36(3):190-192
- CountryChina
- Language:Chinese
-
Abstract:
Hypersensitivity reactions ( HSRs) are the serious problems of taxanes in the clinical appli- cation. These reactions range in severity from mild flushing and itching to bronchospasm, dyspnea and signifi-cant alterations in blood pressure with loss of consciousness or not, and death in some rare cases. Nevertheless, HSRs are often reported only sporadically in clinical trials or as case reports. The vague or inconsistent termi-nology used to describe these reactions may reflect our poor understanding of their pathophysiology. This article will reviews the advancement of taxanes HSRs.
