Correlation between gene polymorphisms of IL-2,IL-6 and TNF-α in workers exposed to rare earth dust and their lung ventilation function
10.3760/cma.j.issn.0254-5098.2009.02.027
- VernacularTitle:含钍稀土粉尘致TNF-α、Il-2和Il-6基因多态性对肺通气功能的影响
- Author:
Xuesong QI
;
Zuohong HAO
;
Huimin LU
;
Chunyan WANG
;
Wei ZHANG
;
Ping WANG
;
Shuxia HAO
;
Xu SU
- Publication Type:Journal Article
- Keywords:
IL2;
IL-6;
TNF-α;
Gene polymorphism;
Lung ventilation dysfunction
- From:
Chinese Journal of Radiological Medicine and Protection
2009;29(2):199-201
- CountryChina
- Language:Chinese
-
Abstract:
Objective To study the relationship between lung ventilation function of workers exposed to rare earth dust and their IL-2,IL-6 and TNF-α gene polymorphism.Methods TNF-α gene polymorphism were identified by RFLP-PCR,IL-2 and IL-6 gene polymorphisms were identified by PCR-CTPP analysis.Lung ventilation function was deteced by instrument of ventilation function.Results Compared with controls,there was no statistic significance in frequencies distribution of TNF-α gene polymorphism(X2=4.03,P>0.05),IL-2 gene polymorphism(X2=2.21,P>0.05)and IL-6 gene polymorphism(X2=1.05,P>0.05).Compared with IL-2 gene wild type,IL-2 homozygote type increased the risk of lung ventilation dysfunction by 4.29 folds(95% CI 1.09~16.9).Conclusions Compared with controls,incidence of ventilation function of workers exposed to rare earth dust is in ascending trend.IL-2(G/G)gene type induces more serious inflammation reaction than the others.