Relationship between Calpain10 gene polymorphisms and diabetes in familial type 2 diabetes mellitus of Uygur in Xinjiang

VernacularTitle:Calpain10基因多态性与维吾尔族2型糖尿病患者亲级关系的研究
Author: Yong FAN ; Rouzi XIANMUSIYA ; Zijing XIE ; Yan XIAO ; Saigang WANG
Publication Type:Journal Article
Keywords: Uygur; Diabetes mellities,type 2; Capain10; Polymorphism,genetic; Heritability
From: Chinese Journal of Endocrinology and Metabolism 2009;25(2):144-146
CountryChina
Language:Chinese
Abstract: Objective To analyse the relationship between Calpain10 gene UCSNP43 and UCSNP44 poly morphisms and diabetes in familial type 2 diabetes mellitus of Uygur in Xinjiang.Methods Sixty-two Uygur type 2 diabetic families were enrolled.The polymorphisms of Calpain10 gene UCSNP43 and UCSNP44 were measured by SNP-stream of gene chip.Results (1) The heritability of the first degree relative and the second degree relative in Uygur familial type 2 diabetes were 0.578 and 0.032.(2)There was no difference between UCSNP43 and UCSNP44 polymorphisms of the first and second degree relatives in familial type 2 diabetes mellitus.(3)The carriers of USCNP43 AA genotype had higher body mass index and fasting insulin than GG and GA genotypes carriers.Conclu sion With the downgrading of the familial relationship,the heritability of type 2 diabetes mellitus was decreasing. The carriers of UCSNP43 AA genotype might have higher insulin resistance than those with GG and AG genotypes.