Gene therapy and cutaneous wound healing
10.3760/cma.j.issn.1673-4203.2009.04.024
- VernacularTitle:基因治疗与皮肤创面愈合
- Author:
Ping ZHU
;
Li YAN
- Publication Type:Journal Article
- Keywords:
gene therapy;
wound healing;
skin;
clinical trials
- From:
International Journal of Surgery
2009;36(4):281-284
- CountryChina
- Language:Chinese
-
Abstract:
Cutaneous wound healing is a complicated multiatep process with numerous mediators that act in a network of activation and inhibition processes. Nonhealing chronic wounds decrease the quality of Life. Recombinant growth factors, currently used in clinic, fail to provide a sustained repair function at the wound due to their inadequate biological availability and transient half-time. Recent attention has focused on gene therapy, which might become a significant treatment modality for those wound healing pathologies refractory to other wound management approaches. This review discusses the potentials and limitations of current genetherapy for the treatment of wounds, current ongoing clinical trials, and possible future directions in this exciting field.
