The role of FOXO transcription factors in neuronal apoptosis after cerebral ischemia
10.3760/cma.j.issn.1673-4165.2009.03.013
- VernacularTitle:FOXO转录因子在脑缺血后神经元凋亡诱导中的作用
- Author:
Tao WANG
;
En XU
- Publication Type:Journal Article
- Keywords:
FOXO transcription factors;
apoptosis;
cerebral ischemia;
protein kinase B
- From:
International Journal of Cerebrovascular Diseases
2009;17(3):220-224
- CountryChina
- Language:Chinese
-
Abstract:
Protein kinase B (PKB), a serine/threonine kinase Akt, regulates many vital cellular functions, such as cell apoptosis, cell cycle progression and glucose metabolism, etc. Akt/PKB carries out these functions mainly through phosphorylation of a number of cellular substrates. As one of the important substrates of Akt, FOXO transcription factors have attracted more and more attention in regulating cell cycle and apoptosis. FOXO transcription factors are primarily regulated by the phosphatidylinositol 3-kinase/Akt signal pathway via phosphorylation,and re-positioning accompanied by sub-cellular distribution. This article reviews the role of FOXO transcri ption factors in neuronal apoptosis after cerebral ischemia.
