Impact of human resistin on glucose uptake in adipocytes and its mechanism
10.3760/cma.j.issn.1000-6699.2009.02.023
- VernacularTitle:人抵抗素对脂肪细胞摄取葡萄糖的影响及其机制研究
- Author:
Chunhua SHENG
;
Yong JIN
;
Yinghong ZHANG
;
Shen GAO
;
Lisha BU
;
Shaojuan YANG
;
Guizhen ZHANG
- Publication Type:Journal Article
- Keywords:
Human resistin;
Adipocytes;
Glucose uptake;
Adipogenesis;
Metformin
- From:
Chinese Journal of Endocrinology and Metabolism
2009;25(2):197-199
- CountryChina
- Language:Chinese
-
Abstract:
The human resistin expression vector was constructed and transfected into cells to observe its effects on glucose uptake in adipocytes,cell proliferation and differentiation.The results suggested that human resistin impaired glucose uptake in adipoeytes via stimulating proliferation of preadipocytes and suppressing adipocyte differentiation.Metformin reversed the inhibition imposed by resistin on adipogenesis.
