Relationship between insulin resistance and oxidative stress caused by elevated concentration of free fatty acids
10.3760/cma.j.issn.1000-6699.2009.02.026
- VernacularTitle:高游离脂肪酸血症所致胰岛素抵抗与氧化应激的关系
- Author:
Zhiming LU
;
Yerong YU
;
Chun WANG
;
Xiangxun ZHANG
- Publication Type:Journal Article
- Keywords:
Fatty acids,nonesterified;
Oxidative stress;
Insulin resistance;
Glutathione
- From:
Chinese Journal of Endocrinology and Metabolism
2009;25(2):205-207
- CountryChina
- Language:Chinese
-
Abstract:
The relationship between elevated concentration of circulating free fatty acids (FFA) and insulin resistance wag studied,and the pathophysiological mechanism of insulin resistance,especially focused on oxidative stress,was explored.It was found that the elevated circulating FFA level led to insulin resistance in rats, which was partly caused by oxidative stress,and that antioxidative treatment was able to reverse the pathologic change.As a result of enhancing reactive oxygen species production[(886±105 vs 427±42)mmol/L,P<0.05] and disrupting antioxidant[(272±47 vs 561±36)μmol/L,P<0.05],elevated concentration of FFA may induce oxidative stress.
