Association of gene polymorphism in promoter region of adiponectin gene and carotid artery intima-media thickness in patients with type 2 diabetes mellitus of Fujian

VernacularTitle:福建地区2型糖尿病患者脂联素基因启动子区多态性与颈动脉内膜中层厚度有关
Author: Qingyan CAI ; Yaxiong SHI ; Yongjia LI ; Geng TAO
Publication Type:Journal Article
Keywords: Adiponectin; Polymorphism,restriction fragment length; Diabetes mellitus,type 2; Carotid artery; Intima-media thickness
From: Chinese Journal of Endocrinology and Metabolism 2009;25(2):136-138
CountryChina
Language:Chinese
Abstract: Objective To explore the association of-11377 site single nucleotide polymorphism in promoter region of adiponectin gene and carotid intima-media thickness(CIMT)in patients with type 2 diabetes mellitus.Methods The adiponectin gene-11377C→G polymorphism was identified by PCR-restriction fragment length polymorphism(RFLP)in 504 patients with type 2 diabetes mellitus(250 patients with increased CIMT and254 Datients with normal CIMT). Serum lipid and fasting plasma glucose were detected by full automatic biochemical analysor.fasting serum insulin(FINS) was measured by radioimmunoassay,and serum adiponectin level was assessed by ELISA.Results The frequencies of adiponectin gene-11377C→G genotype and allele were different between type 2 diabetic patients with normal and increased CIMT(P