Insulin reverses fatty liver disease in diabetic mice induced with high fat diet
10.3760/cma.j.issn.1000-6699.2009.02.024
- VernacularTitle:胰岛素治疗逆转糖尿病小鼠肝脏的脂肪沉积
- Author:
Yanhun ZHU
;
Xiang CHEN
;
Ming LI
;
Qiuqiong YU
;
Weiping SUN
;
Yan BI
;
Jianping WENG
- Publication Type:Journal Article
- Keywords:
Fatty liver;
Diabetes mellitus;
Glargine
- From:
Chinese Journal of Endocrinology and Metabolism
2009;25(2):200-202
- CountryChina
- Language:Chinese
-
Abstract:
The effect of insulin treatment on fatty liver was investigated in diabetic mice fed with high-fat diet.C57 BL/6J mice were fed with high fat diet for 12 weeks,and then treated with Glargine for 4 weeks.The results showed that during intraperitoneal glucose tolerance test,blood glucose,serum total cholesterol and triglyceride(TG) were significantly lower in insulin-treated high fat group than those in untreated ones(P<0.05).The hepatic histology showed minimal or barely visible fat in hepmic cells along with TG content in liver decreasing by 20.71%. The results suggest that insulin ameliorates hepatic intracellular lipid accumulation induced by high fat diet.
