The changes of plasma neuropeptide Y and neurotensin levels in patients with heart failure
10.3760/cma.j.issn.1673-4904.2009.10.005
- VernacularTitle:心力衰竭患者血浆神经肽Y、神经降压素水平变化
- Author:
Runmei LIU
;
Yunfeng XIA
;
Yaxin YIN
;
Hongxia ZHAI
;
Liang LI
;
Jinjin ZHANG
;
Haiwei CHEN
;
Sujuan CHEN
- Publication Type:Journal Article
- Keywords:
Heart failure,congestive;
Neuropeptide Y;
Neurotensin
- From:
Chinese Journal of Postgraduates of Medicine
2009;32(10):13-15
- CountryChina
- Language:Chinese
-
Abstract:
Objective To observe the changes of plasma neuropeptide Y (NPY) and neurotensin (NT) levels in patients with heart failure and investigate their clinical significance. Methods The levels of plasma NPY, NT of 76 patients with heart failure and 28 normal controls were determined by radioimmunoassay (RIA). The color echocardiogram was used to evaluate the cardiac structure, function and left ventricular ejection fraction (LVEF). Results The level of plasma NPY in patients with heart failure [(159.7 ± 56.3) ng/L] was higher than that in normal controls [(120.8 ± 51.9) ng/L] (P < 0.05), the level of plasma NT [(69.5 ± 29.6) ng/L] was significantly lower than that in normal controls [(99.1 ± 19.3) ng/L] (P < 0.01). Following the severity of heart failure, the level of plasma NPY increased, and the level of plasma NT decreased. The level of LVEF had negative correlative relationship with the level of plasma NPY (γ = -0.31, P < 0.05) and positive correlative relationship with the level of plasma NT (γ = 0.28, P < 0.05). The level of plasma NPY and NT in patients with heart failure had negative correlative relationship (γ = -0.26, P < 0.05). Conclusions The levels of plasma NPY, NT in patients with heart failure are unbalanced. This unbalance may participate in the damage of cardiac function.
