Relationship between platelet activating factor acetylhydrolase genetic polymorphism and platelet activation and prognosis in patients with ischemic stroke
10.3760/cma.j.issn.1673-4904.2009.10.010
- VernacularTitle:血小板活化因子乙酰水解酶基因多态性与缺血性脑卒中患者血小板活化和预后关系的研究
- Author:
Jianping ZHOU
;
Yuxia SHEN
;
Kui YIN
;
Chen WANG
;
Yuchen QIU
;
Wanxiang WANG
;
Jianjin DENG
- Publication Type:Journal Article
- Keywords:
Cerebrovascular anident;
Platelet activation;
1-Alkyl-2-acetylglycerophospho-choline esterase;
Gene polymorphism
- From:
Chinese Journal of Postgraduates of Medicine
2009;32(10):27-31
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the corelation between platelet activating factor acetylhydrolase (PAF-AH) genetic polymorphism and ischemic stroke. Methods The plasma PAF-AH genotype was determined in 205 patients with iachemic stroke and 114 normal subjects by the polymerase chain reaction. The levels of plasma platelet activating factor (PAF), platelet α-granule membrane glycoprotein-140(GMP-140), β-thromboglobulin (β-TG) and the levels of platelet factor 4 (PF4) were analyzed. Results The prevalence of the mutation genotype and plasma PAF, GMP-140, β-TG and PF4 in the patients with isehemic stroke [42.44%,(91.08 ± 39.10) ng/L, (36.46 ± 13.10) μg/L, (41.75 ± 11.18) μg/L, (29.05 ± 9.16) g/L, respectively] were significantly higher than those in the controls[21.05%,(64.30 ± 18.81) ng/L, (18.27 ± 7.68) μg/L, (30.94 ± 8.47) μg/L, (18.75 ± 6.06) μg/L](P< 0.01). The levels of plasma PAF, GMP-140 were significantly higher in mutation genotype patients than those in the normal genotype patients (P < 0.01). Conclusions The activation function of platelet in the acute phase of patients with ischemic stroke increases, and it is associated with genetic polymorphism of PAF-AH. The PAF-AH gene mutation may be a novel genetic marker for high risk of ischemic stroke.
