Expression of JNK/SAPK in lung and bronchus of radon-exposed mice

VernacularTitle:氡染毒小鼠肺及支气管中JNK/SAPK表达的研究
Author: Zhiying GUO ; Mei TIAN ; Jianxiang LIU ; Jianlei RUAN ; Chunnan PIAO ; Xu SU
Publication Type:Journal Article
Keywords: Radon and its progeny; Mice; Exposure; JNK/SAPK(c-Jun NH2-terminal kinase/stress activated protein kinase)
From: Chinese Journal of Radiological Medicine and Protection 2009;29(2):192-195
CountryChina
Language:Chinese
Abstract: Objective To study the expression of JNK/SAPK(c-Jun NH2-terminal kinase/stress activated protein kinase)in lung and bronchus of radon-exposed mice.Methods Male BALB/c mice were exposed to radon and its progeny with the cumulative dose of 0.02,30 or 60 working level month(WLM),respectively.The expression levels of JNK/SAPK in lung and bronchus were determined with Real-Time PCR,Western blot and immunohistochemistry methods.Results The JNK mRNA levels in lung tissues of mice exposed to radon of 30 and 60 WLM were higher than those of the control by 3.56 and 2.96 times,respectively.The relative expression levels of JNK and phospho-JNK proteins were higher than those of the control by using Western blot and immunohistochemistry methods.Condusiom Expose to the radon and its progeny might activate the JNK/SAPK intracellular signaling pathway.