Effect of activated kupffer cells on immune tolerance after liver transplantation
10.3760/cma.j.issn.1673-4203.2009.04.021
- VernacularTitle:Kupffer细胞激活与肝移植免疫耐受
- Author:
Tian XIA
;
Yon CHEN
;
Jianping GONG
- Publication Type:Journal Article
- Keywords:
kupffer cells;
cytokine;
immune modulation;
immune tolerance
- From:
International Journal of Surgery
2009;36(4):272-275
- CountryChina
- Language:Chinese
-
Abstract:
Until now, the exactly effect of Kupffer cells (KCs) on inducing immune tolerance or aggravating acute rejection is still unknown. Activated by various way after liver transplantation, have the ability of phagucytosis the apoptositic T cells, up-regulated expression of FasL and many Th2/Th3 cytokines, such as interleukin-10 and transforming growth factor-lB. These up-regulated cytokines could induce the apoptosis of Th1 cells and enhance the proliferation and differentiation of the Th2 cells, finally induce the immune tolerance, However, the activated KCs also have the ability of expression many cytokine-dependent molecules,such as class Ⅱ major histocompatibility antigens, adhesion molecule and costimulatory molecules which could enhance the function of the antigen presentation, increase the expression of Thl cytokine and aggravate the acute rejection after liver transplantation. It maybe relate to the ratio of theTh1/Th2 cells determined by the complicated net of the cytokine produced by the activated Kupffer cells: the predominance of Th2 cells could induce the immune tolerance, on the contrary, the acute rejection proceed.
