Musclin gene overexpression in skeletal muscle of rats with long-term high-fat diet and its correlation with insulin resistance
10.3760/cma.j.issn.1000-6699.2009.02.027
- VernacularTitle:长期高脂饲养大鼠骨骼肌musclin表达上调及其与胰岛素抵抗的相关性
- Author:
Lingling CAO
;
Li YUAN
;
Jiangxiang XU
;
Zhiqiang LIU
;
Xia WANG
;
Bei ZHANG
;
Haiyan QIU
;
Guoling XU
;
Zhaosheng TANG
- Publication Type:Journal Article
- Keywords:
Insulin resistance;
Musclin;
Glucose transporter 4;
Gene expression
- From:
Chinese Journal of Endocrinology and Metabolism
2009;25(2):208-209
- CountryChina
- Language:Chinese
-
Abstract:
The expression of musclin gene in skeletal muscle of rats fed with high-fat diet and its correlation to insulin resistance.diabetes mellitus and GLUT4 were explored.The results showed that musclin expressin was up-regulated(1.39±0.36 vs 0.31±0.07,P<0.01)in skeletal muscle of rats fed with high-fat diet, suggesting that this finding may be related with insulin resistance and involvement of GLUT-4 expression(1.27 4± 0.32 vs 1.84±0.24.P<0.01).
