Effect of angiotensin receptor blocker on the expressions of NF-κB PPARγ in adipose tissue of high-fat- diet induced insulin resistant rats
10.3760/cma.j.issn.1000-6699.2009.02.028
- VernacularTitle:血管紧张素受体阻断剂对高脂诱导的胰岛素抵抗大鼠脂肪组织NF-κB、PPARγ/表达的影响
- Author:
Xiaoling LIU
;
Li YUAN
;
Caihong GUO
;
Yan HUANG
;
Aimin DU
;
Lili ZHANG
- Publication Type:Journal Article
- Keywords:
Peroxisome proliferators-activated receptor gamma;
NF-κB;
Angiotensin receptor blocker
- From:
Chinese Journal of Endocrinology and Metabolism
2009;25(2):210-211
- CountryChina
- Language:Chinese
-
Abstract:
The expressions of NF-κB and PPARγ were increased in adipose tissue of insulin resistant rats.The angiotensin receptor blocker decreased NF-κB protein expression by 21%,increased PPARγ protein expression by 28%and diminished adipocyte size,suggesting that these findings may be involved in the improvement of obesity-induced inflammation and insulin resisitance.
