Effect of the unbalanced expressions of VEGF and PEDF on diabetic nephropathy
10.3760/cma.j.issn.1000-6699.2009.02.025
- VernacularTitle:VEGF和色素上皮衍生因子的表达失衡对糖尿病肾病的影响
- Author:
Jing LI
;
Zhenjin LI
;
Jing CUI
;
Shue WANG
;
Yan BAO
;
Yingchun YE
- Publication Type:Journal Article
- Keywords:
Vsscular endothelial growth factor;
Pigment epithelium derived factor;
Diabetic nephropathies;
Fihroblasts;
Tubulointerstitium
- From:
Chinese Journal of Endocrinology and Metabolism
2009;25(2):203-205
- CountryChina
- Language:Chinese
-
Abstract:
The expressions of vascular endothelial growth factor(VEGF)and pigment epithelium derived factor(PEDF)in the tubulointerstitium were determined by immunohistochemistry in the streptozotoein-induced diahetic rats.The mRNA expressions of VEGF and PEDF in normal rat kidney (NRK) were measured by using RT-PCR under different high glucose conditions.The results showed that VEGF expression increased and PEDF expression decreased in the kidney tissue of the streptozotocin-induced diabetic rats.Hiish glucose increased VEGF expression and decreased PEDF expression in N RK cells in a time-and dose-dependent manner.The unbalanced expressions of VEGF and PEDF may play an important role in the occurrence and progression of diabetic nephropathy.
