Effect of estrogens on breast cancer through SDF-1/CXCR4 signaling path-ways
10.3760/cma.j.issn.1673-4203.2009.01.020
- VernacularTitle:雌激素通过SDF-1/CXCR4信号通路对乳腺癌的影响
- Author:
Fengliang ZHANG
;
Hua KANG
- Publication Type:Journal Article
- Keywords:
estrogen;
breast cancer;
stromal cell-derived factor-1;
CXCR4
- From:
International Journal of Surgery
2009;36(1):51-54
- CountryChina
- Language:Chinese
-
Abstract:
Breast cancer is a kind of hormone-dependent tumor,the high level of estrogens is an impor-tant risk factor of breast cancer.There is evidence that estrogens through estrogen receptor (ER) signaling pathways and estrogen metabolic products participate in the development and progression of breast cancer.Recentally,studies demonstrated that SDF-1 and its receptor CXCR4 are involved in breast cancer.Estro-gens play an important role in the growth,proliferation and metastasis of breast eaneers through SDF-1/CX-CR4 signaling pathways.These findings may'provide a novel therapeutic target for breast cancer.
