Plasma markers of endothelial function in cardio-cerebrovascular diseases
10.3760/cma.j.issn.1673-4165.2009.03.009
- VernacularTitle:血浆内皮功能标志物在心脑血管病中的意义
- Author:
Weihong YANG
- Publication Type:Journal Article
- Keywords:
endothelium,vascular;
von Willebrand factor;
thrombomodulin;
intercellular adhesion molecule-1;
E-selectin;
cardiovascular diseases;
cerebrovascular disorders
- From:
International Journal of Cerebrovascular Diseases
2009;17(3):200-204
- CountryChina
- Language:Chinese
-
Abstract:
Endothelial cells can be activated, and develop dysfunction and damage under the pathological state. Endothelial dysfunction plays a key role in the processes of cardio-cerebrovascular diseases, and can be detected in peripheral blood. The concentration of von Willebrand factor (vWF) predicts the risk of coronary heart disease and stroke; the concentration of soluble thrombomodulin is associated with the prognoses of coronary heart disease and stroke; soluble intercellular ashesion rnolecule-1 (ICAM-1) predicts the risks of carotid athero-sclerosis, coronary heart disease, peripheral arterial disease, and diabetes mellitus; the levels of plasma soluble E-selectin in patients with carotid atherosclerosis, coronary artery disease, and diabetes mellitus are increased; the increased endothelin-1 levels predicts the elevated risk of congestive heart failure. The injection of endothelial progenitor cells is promising to become a novel approach for the treatment of cardio-cerebrovascular diseases.
