Role of autophgy in atherosclerosis and its modulation
10.3760/cma.j.issn.1673-4165.2009.03.014
- VernacularTitle:自噬在动脉粥样硬化中的作用及其调控
- Author:
Tong TONG
;
Yongjun CAO
;
Chunfeng LIU
- Publication Type:Journal Article
- Keywords:
autophagy;
atherosclerosis;
myocytes,smooth muscle;
macrophage;
endothelium,vascular
- From:
International Journal of Cerebrovascular Diseases
2009;17(3):225-228
- CountryChina
- Language:Chinese
-
Abstract:
Autophagy is a process for the degradation of long half-life proteins and organelles via the lysosome system. A large body of evidence indicates that the autophagic phenomena exist in the progressive atherosclerotic plaques. Vascular smooth muscle cells, macrophages, and endothelial cells treated with some stimulants that result in atherosclerosis formation in in vitro experiments, these cells show certain autophagic features, such as myelin-like structures, accumulation of ubiquitinated inclusions in the cytoplasm, and extensive vacuolization. However, although the interests in research on autophagy are increasing, the exact role of autophagy in atherosclerosis remains unclear. Therefore, understanding the underlying cellular and molecular mechanisms of autophagy will provide a new idea for studying the mechanisms and treatment of atherosclerotic disease.
