Naturalistic observation of the effect of donepezil on cognitive function in Alzheimer's disease in memory clinic
10.3760/cma.j.issn.1008-6315.2009.04.004
- VernacularTitle:多奈哌齐治疗阿尔茨海默病患者认知功能的自然观察研究
- Author:
Kai LIN
;
Xin YU
;
Huali WANG
- Publication Type:Journal Article
- Keywords:
Donepezil;
Alzheimer's disease;
Cognitive function;
Naturalistic observation
- From:Clinical Medicine of China
2009;25(4):345-347
- CountryChina
- Language:Chinese
-
Abstract:
Objective To examine the effect of donepezil on cognitive function of Alzheimer's disease from a naturalistic observation in memory clinic.Methods From the subject pool in memory clinic,thirteen patients with mild to moderate Alzheimer's disease(meeting NINCDS-ADRDA criteria of probable AD)were enrolled in the naturalistic observation.Donepezil with dosage of 5 mg daily Was administered.Cognitive Ability Screening Instrument (CASI)Was used to assess the cognitive function,and was administered at baseline,3 and 6 months after treatment with donepezil.Resuits After 6-month treatment with donepezil,the change of score of verbal fluency from baseline Was significant[(4.3±3.1)vs(6.2±2.7),P＜0.05].There was a trend that constructional praxis was also improved after 6-month treatment(P=0.06).The change of scores of other cognitive domains remained the sanle(P＞0.05).Conclusion In the naturalistic observation at memory chnic,donepezil may improve verbal fluency of AD patients,and keep most cognitive function stable.
