The relation of MIF level in serum and the stages and lymphnode metastasis in patients with colorectal cancer
- VernacularTitle:血清中巨噬细胞移动抑制因子表达与大肠癌的分期及淋巴结转移相关性研究
- Author:
Minghao WU
;
Zhan LIU
- Publication Type:Journal Article
- Keywords:
Macrophage migration-inhibitory factors/BL;
Intestinal neoplasms;
Neoplasm staging;
Neoplasm metastasis
- From:
Journal of Chinese Physician
2009;11(4):456-457
- CountryChina
- Language:Chinese
-
Abstract:
Objective To study the relationship between serum macrophage migration inhibitory factor (MIF) levels and clinical features in the patients with colorectal cancer. Methods Enzyme-linked immunosorbent assays was used to detect the concentration of MIF in sera of 75 patients with colorectal cancer (35 case with primary colorectal cancer and 40 cases with lymphnode metastasis of colorectal cancer) and 40 healthy controls. The relationship between serum MIF levels and clinical features was analyzed. Results Serum MIF was found to be significantly elevated in the patients with colorectal cancer(mean value 31.2ng/ml) compared with healthy subjects (mean value 13.6ng/ml) (P <0. 001). The levels of MIF in colorectal cancer were significantly correlated with advanced clinical progression pathology stages (P <0. 05) and lymph node metastasis (P < 0. 05). Conclusions Increased expression level of MIF in serum may promote the pathogenesis of colorectal cancer and M1F is closely associated with the stages and lymph node metastasis of colorectal cancer.
