Postmastectomy hypofractionation radiotherapy in high-risk breast cancer patients: A phase Ⅰ/Ⅱ clinical trial

VernacularTitle:乳腺癌改良根治术后大分割放疗Ⅰ～Ⅱ期临床试验的近期结果
Author: Shulian WANG ; Yexiong LI ; Yongwen SONG ; Jing JIN ; Hui FANG ; Yuan QU ; Zhouguang HUI ; Weihu WANG ; Zihao YU ; Xinfan LIU
Publication Type:Journal Article
Keywords: Breast neoplasms/surgery; Surgery,mastectomy; Breast neoplasms/radiotherapy; Radiotherapy,hypofractionation
From: Chinese Journal of Radiation Oncology 2009;18(3):197-199
CountryChina
Language:Chinese
Abstract: Objective To investigate the efficacy and toxicity of postmastectomy hypofractionation radiotherapy in patients with high-risk breast cancer. Methods Postmastectomy radiation of 43.5 Gy in 15 fractions of 2.9 Gy over 3 weeks was delivered to 38 patients with breast cancer. The incidence of acute radi-ation toxicity and lecoregional recurrence was evaluated. Results With a median follow up of 13 months, all patients were alive. No patient had locoregional recurrence within radiation field. Five (13%) had dis-tant metastases. Five (13%) developed grade 3 radiation dermatitis at 2 to 3 weeks after the course of radia-tion. Three (8%) had grade 2 radiation pneumonitis. Conclusions Hypofractionation radiation of 43.5 Gy in 15 fractions of 2.9 Gy over 3 weeks is effective in the near time for patients with high-risk breast cancer after mastectomy, and the acute toxicities are tolerable.