Comparison of pharmacodynamics of rocuronium in different age children
10.3760/cma.j.issn.0254-1416.2009.03.003
- VernacularTitle:不同年龄患儿罗库溴铵药效学的比较
- Author:
Jinzhu LIU
;
Weigen MA
- Publication Type:Journal Article
- Keywords:
Andrestanoh;
Dose-response relationship,drug;
Age factors;
Child
- From:
Chinese Journal of Anesthesiology
2009;29(3):203-206
- CountryChina
- Language:Chinese
-
Abstract:
Objective To compare pharmacodynamics of rocuronium in neonates,infants,young children and children.Methods One hundred and sixty ASA Ⅰ or Ⅱ pediatric patients undergoing elective surgicalprocedures under total intravenous anesthesia(TIVA)were divided into 4 groups according to ages(n=40 each):neonate group(0-28d),infant group(28 d0.05).Onset time of muscle relaxation.clinical duration and total duration were significantly shorter and recovery index lower in the other 3 groups than in neonate group(P<0.01).but there was nosignificant difference in the duration of peak effect among the 4 groups(P>0.05).ED50,ED90 and ED95 of rocuronium were significantly higher in children group than in young children group(P<0.01).Conclusions There are significant differences in dose-effect and time-effect relationships among different age children and neonate is more sensitive to rocuronium than the other age children.
