Clinical and laboratory diagnosis of adult hemophagocytic syndrome

VernacularTitle:成人嗜血细胞综合征的临床与实验诊断
Author: Hongyu ZHANG ; Qingxiang MENG ; Jin LIU ; Liping PANG ; Jun WANG ; Lei XU ; Jia FENG ; Wenli ZHANG ; Qian ZHAGN ; Lihua SUN ; Fengluan ZHONG ; Haichan XU ; Jiren YU
Publication Type:Journal Article
Keywords: Adult hemophagocytic syndrome; Clinical diagnosis; Laboratory diagnosis
From: Clinical Medicine of China 2009;25(5):509-512
CountryChina
Language:Chinese
Abstract: Objective To investigate the clinical and laboratory diagnosis of adult hemophagocytic syn-drome (HPS) . Methods Clinical data of 24 patients with HPS from 2000 to 2008 were retrospectively analyzed. Results Of the 24 HPS cases, 12 had a malignant associated hemophagocytic syndrome (MHAS), and 10 were fi-nally diagnosed by bone marrow immunohistochemist ;Of 12 cases in non-MAHS group,4 were with virus associated hemophagocytic syndrome (VAHS), and 4 were of the other infections, whereas 4 patients diagnosed of immune associated HS (MAS). There were significant difference in onset age, mortality, serum lactate dehydrogenase (LDH) and serum ferritin(FER) and neutrophilic NAP between non-MAHS group and MAHS group(P <0.01 ,P<0.05). In all cases bone marrow biopsy showed significant differences in cytological and pathological features between MAHS group and non-MAHS group. Conclusion Etiology,immunology,and bone marrow cell biopsy and pathology as well contribute to the diagnosis and typing of HPS and will give a guide to the therapy.