Improved renal function in advanced renal cell carcinoma patient by targeted therapy
10.3760/cma.j.issn.1000-6702.2009.05.008
- VernacularTitle:多靶点药物治疗晚期肾癌肾功能改善的临床观察
- Author:
Rongming ZHANG
;
Zhoujun SHEN
;
Wei HE
;
Kun SHAO
;
Haofei WANG
;
Juping ZHAO
;
Jun DAI
- Publication Type:Journal Article
- Keywords:
Kidney neoplasms;
Neoplasm metastasis;
Renal insufficiency;
Sorafenib
- From:
Chinese Journal of Urology
2009;30(5):317-319
- CountryChina
- Language:Chinese
-
Abstract:
Objective To report and analyze the renal function improvement in a case with ad-vanced bilateral renal cell carcinoma after targeted therapy. Methods The patient was a 60-year-old man who complained of lower back pain for 1 month. Ultrasound and CT scan detected bilateral renal masses, left lesion was 11.0 cm×9.4 cm×8.5 cm, and the right one was 3.5 cm×4.3 cm×4.1 cm. X-ray examination showed metastatic lesions in liver and lower right lung. GFR was 20.39 ml/min of left kidney, 25.40 ml/min of right kidney. The renal biopsy confirmed renal clear cell carcinoma. Sorafenib was administrated 400 mg twice or once daily for 12 weeks. Results After the targeted therapy, the decreased bilateral kidney tumor sizes were identified by CT scan. There was liquid nec-rosis in the tumor, and no new metastatic lesion detected. The kidney function was improved as well. The total GFR increased to 71.38 ml/min. Left kidney GFR increased to 31.57 ml/min, right kidney GFR increased to 39.81 ml/min, respectively. Conclusion Targeted therapy could improve renal function in advanced renal cell carcinoma cases by controlling tumor development.
