Expression and significance of HSP70 and p57-Idp2 in giant cell tumor of bone
- VernacularTitle:HSP70与p57kip2在骨巨细胞瘤中的表达及意义
- Author:
Min XU
;
Dan PENG
;
Zhihong LI
- Publication Type:Journal Article
- Keywords:
Heat-shock proteins 70/BI;
Cyclin-dependent kinases/AI/BI;
Giant cell tumor of bone/ME
- From:
Journal of Chinese Physician
2009;11(4):443-446
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the relation between the expression of HSP70 and p57kip2 in C, CT and Enneking surgical classifi-cation by detecting expression of HSP70 and p57kip2. Methods 30 cases of GCT were collected, including surgical operation specimens and 13 cases of osteochondroma were taken as control group. The expression of HSP70 and p57kip2 were detected, and the relation between the ex-pression of HSP70 and p57kip2 and Enneking surgical classification and prognosis of GCT were analyzed. Results With the increase of tumor Enneking surgical grades, the positive rate of HSP70 was increased and the negative rate of p57kip2 was decreased. Expression rates of HSP70 were 22. 2%, 88.9% ,100% in grades of 1～3 and expression rates of p57kip2 were 88. 9%, 88.9%, 33.3% in grades of 1～3. There was a negative correlation between HSPTo and p.57kip2 expression. Conclusions HSP70 and p57kip2 may play a role in the genesis, and develop-ment of giant cell tumor of bone, and it can be helpful for surgical classification and prognesis of GCT.
