Assessment of propofol-induced psychic dependence in rats
10.3760/cma.j.issn.0254-1416.2009.03.013
- VernacularTitle:异丙酚诱发大鼠精神依赖性的评价
- Author:
Benfu WANG
;
Shengwei JIN
;
Miaojun LAI
;
Shuaien TANG
;
Hong CAO
;
Han LIN
;
Wenhua ZHOU
;
Fuqiang ZHANG
;
Jun LI
;
Huaqiang ZHU
;
Qingquan LIAN
- Publication Type:Journal Article
- Keywords:
Propofol;
Substance abuse,intravenous
- From:
Chinese Journal of Anesthesiology
2009;29(3):236-239
- CountryChina
- Language:Chinese
-
Abstract:
Objective To assess whether propofol call induce stable psychic dependence in the rats by self-administration experiment. Methods Twenty-four male SD rats 14 weeks old weighing 240一270 mg were studied. Anesthesia was performed with intraperitoneal injection of 3%sodium pentoharbitsl 40 ms/kg and atropine 03 mg/kg.A catheter wag inserted into the right external jugular vein. Penicillin(100 000 U)0.2 ml wag injected through the external jugular vein for anti-infection and heparin sodium(50U/ml)0.1 ml for anticoagulation. The self-administration experiment of 14 days was started after the 7 days of recovery. All the rats were randomly divided into 4 groups(n=6 each):contontrol group(C),propofol 0.56 mg/kg/l group(P1),propofol 1.00 mg/kg group(P2)and pmpofol 1.70 ms/kg group(P3).The experimental events were controlled by a computer with 50 times of the maximum injection per day.The times ofactive and inactive nose-poke response and times of drug iniection were recorded per day.Results Compared with group C and P1,the times of active nosepoke response and injections were significantly increased in group P2 and P3(P<0.01).The times of active nosepoke response and injections per day were significantly increased in group P3 than in group P2(P(0.01).There was no significant difference in the times of active nose-poke response and injections between group C and P1.There was no significant difference in inactive nose-poke resporme between the 4 groups.And the total daily doses of propofol injected in the last 3 days were significantly increased in a dose-dependent manner.Conclusion Propefol can induce the development of psychological dependence in rata and it is related to the dosage.
