Effects of long-term exposure to low-level sevoflurane on reproductive function in mice
10.3760/cma.j.issn.0254-1416.2009.03.015
- VernacularTitle:长期吸入低浓度七氟烷对小鼠生殖功能的影响
- Author:
Shigao WANG
;
Han LIN
;
Xuefei YE
;
Shenghua XIAO
;
Renshan GE
;
Hong CAO
;
Jun LI
;
Qingquan LIAN
- Publication Type:Journal Article
- Keywords:
Reproduction;
Sevoflurane
- From:
Chinese Journal of Anesthesiology
2009;29(3):243-245
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate rite effects of loag-term exposure to low-level sevoflurane on reproductive function in mice.Method F0ny male ICR mice,aged 60 d,weighlag 20-25 g,were randomly divided into 4 groups(n=10 each):control group received no sevoflunme(C);group S1-3 were exposed to 0.003%.0.01% and 0.03% sevoflurane 2 h per day for 5 consecutive days per week for 8 weeks respectively. The mice were then sacrificed at the end of the 8 weeks.The testes and epididymis were emoved and sampled for determination of the activities of total lactic dehydregenase(LDH)and lactic dehydrogenase-X(LDH-X),and the motility rate,amount,and aberration rate of sperm.Testicular uhrastructure were observed by transmission electron microscopy.Results The sperm motifity nne were significantly lower.the sperm aberration rate higher and the activity of LDH-X lower in group S3 than in group C(P<0.05),but there was no significant difference in the above parametem between group SI and group S2(P>0.05).The pathology changed of testes occurred only in group S3 among the 3 groups.Conclusion Long-term exposure to 0.03% sevoflurane can result in the abnormality of the reproductive function in male mice but exposure to≤0.01%sevoflurane dose not.
