High-risk human papillomaviral infection characterized by pseudocondyloma of vulvae

VernacularTitle:临床表现为假性湿疣的高危型HPV感染
Author: Juan XU ; Jing WANG ; Xuedong LU ; Qin HE ; Jiayuan CHEN ; Li XIANG ; Xiameng HUANG
Publication Type:Journal Article
Keywords: Pseudocondyloma of vulvae; Condyloma acuminata; Human papillomavirus
From: Chinese Journal of Dermatology 2009;42(5):303-304
CountryChina
Language:Chinese
Abstract: Objective To investigate the clinical features and human papillomavims (HPV) types in 12 cases of HPV infection characterized by pseudocondyloma of vulvae. Methods Twelve women, who had a history of sexual behavior with non-spouses and presented with pseudocondyloma of vulvae, were included in this study. Tissue specimens were scraped or resected from the lesions of pseudocondyloma of vulvae. PCR-based reverse hybridization assay was performed to determine the genotypes of HPV. Results All the 12 specimens were HPV positive. The reverse hybridization assay generated 13 subgenotypes of HPV, including 3 low-risk genotypes (11, 42 and 43) and 10 high-risk genotypes (16, 18, 31, 33, 35, 39, 51, 52, 58 and 59). All the patients were found to be infected by at least one high-risk genotype. Of the 12 patients, 4 were infected by single type of HPV, 6 by 2 types of HPV, and 2 by 3 or 4 genotypes of HPV. Conclusion The patients characterized by pseudocondyloma of vulvae may suffer from high-risk HPV infection.