Expression of hypoxia-inducible factor 1 alpha, vascular endothelial growth factor and angiopoie-tin-2 in tissues of condyloma acuminatum in pregnant women
10.3760/cma.j.issn.0412-4030.2009.05.010
- VernacularTitle:HIF-1α、VEGF及Ang-2在妊娠伴尖锐湿疣组织中的表达
- Author:
Lin ZHOU
;
Dan LUO
- Publication Type:Journal Article
- Keywords:
Condylomata acuminata;
Pregnancy;
Hypoxia-inducible factor 1,alpha subunit;
Vas-cular endothelial growth factors;
Angiopoietin-2
- From:
Chinese Journal of Dermatology
2009;42(5):324-326
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the expression and significance of hypoxia-inducible factor 1 alpha (HIF- 1α), vascular endothelial growth factor (VEGF) and angiopoietin-2 (Ang-2) in tissues of condy- loma acuminatum (CA) in pregnant women. Methods Tissue specimens were obtained from the lesions of 30 pregnant women with CA and 30 non-pregnant women with CA, and from the vulva of 15 normal preg- nant women. By immunohistochemical staining, the expressions of HIF -1α, VEGF and Ang-2 were detected in these specimens. Results The expression rates of HIF -1α,VEGF and Ang-2 were 86.67%, 93.33% and 83.33% in pregnant women with CA, respectively, 63.33%, 66.67% and 53.33% in non-pregnant women with CA, respectively, and 0, 6.67% and 0 in normal women, respectively. Enhanced expressions of HIF -1α,VEGF and Ang-2 were observed in pregnant women with CA compared with the latter two groups (P < 0.05). In pregnant women with CA, a significant correlation was noted between the expression of HIF -1α and VEGF (r = 0.412, P < 0.01) and between the expression of Ang-2 and VEGF (r = 0.460, P < 0.01). Further more, the expression of HIF -1α, VEGF and Ang-2 positively correlated with each other in non-preg- nant women with CA. Conclusion In tissues of CA in pregnant women, HIF-1α,Ang-2 and VEGF are over expressed, which may be related to angiogenesis.
