Study on expression of NF-κB/p65 in nasal NK/T cell lymphomas
- VernacularTitle:NF-κB/p65在鼻NK/T淋巴瘤中的表达及意义
- Author:
Qunying LIANG
;
Aiju FENG
;
Sen HE
;
Xiuqin LIU
;
Ya LIU
- Publication Type:Journal Article
- Keywords:
NF-kappa B/BI;
Oncogene protein p65(gag-jun)/BI;
Nose neoplasms/ME;
Lymphoma,T-cell/ME
- From:
Journal of Chinese Physician
2009;11(4):477-479
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the expression of NF-κB/p65 in nasal NK/T cell lymphomas. Methods Immunohistochemis-try and TUNEL were used to study the expression of NF-KB/p65 and cell apoptosis in 23 nasal NK/T cell lymphoma samples and 14 benign lymph node lesions. Results The NF-KB/p65 positive rates were 43.5% (10/23). The expression of NF-κB/p65 was negative correlated with apoptotic index among 23 nasal NK/T cell lymphomas(P <0. 05). The mean survival period in patients expressed NF-KB/p65 was sig-nificantly shorter than that in negative group(P <0. 05). Conclusions Apoptosis inhibited by overexpression of NF-κB/p65 might be in-volved in the development of nasal NK/T cell lymphoma. NF-κB/p65 expression may be an unfavorable prognostic factor of nasal NK/T cell lymphoma.
