Correlation of perfusion CT findings with microvessel density and vascular endothelial growth factor expression in renal cell cancer
10.3760/cma.j.issn.1000-6702.2009.05.004
- VernacularTitle:肾细胞癌灌注CT表现与微血管密度及血管内皮生长因子表达的相关性
- Author:
Yan CHEN
;
Jin ZHANG
;
Zheng ZHU
;
Jingrui DAI
;
Xiaoli FENG
;
Haizhen LU
;
Chunwu ZHOU
- Publication Type:Journal Article
- Keywords:
Kidney neoplasms;
Carcinoma;
Tomography,spiral computed;
Microvessel density;
Vascular endothelial growth factor
- From:
Chinese Journal of Urology
2009;30(5):306-308
- CountryChina
- Language:Chinese
-
Abstract:
Objective To study the perfusion imaging features of renal cell cancer(RCC) and their correlation with microvessel density(MVD) and vascular endothelial growth factor(VEGF) ex-pression status. Methods Dynamic contrast-enhanced multislice spiral CT was performed preopera-tively in 73 cases with histologically proven RCC (65 cases of clear cell carcinoma, 3 of papillary ade-nocarcinoma, and 5 of chromophobic carcinoma). Blood volume (BV), blood flow (BF), mean transit time (MTT), and permeability surface area product (PS) of tumors were recorded. MVD and VEGF expression status were studied by immunohistochemial staining. Results The mean BV, BF, MTT negative in 35 (47.9 %) cases, slightly positive in 24 (32.9 %) cases, moderate positive in 10 (13.7 %) cases, and intensively positive in 4 (5.5 %) cases. MVD of RCC was positively correlated with BV, BF and PS (P<0.01),and negatively correlated with MTT (P<0.05). No relationship was found be-tween the expression of VEGF and perfusion CT parameters. Conclusion Perfusion CT scan is use-ful to evaluate the angiogenesis status of RCC.
