Association of insulin resistance with spontaneous recanalization of infarct-related arteries in patients with a-cute myocardial infarction
10.3760/cma.j.issn.1008-6315.2009.05.010
- VernacularTitle:胰岛素抵抗与急性心肌梗死患者梗死相关动脉自发再通的关系
- Author:
Liangping ZHAO
;
Ankang LU
;
Haifeng LIU
;
Qi ZHANG
;
Fenghua DING
;
Ruiyan ZHANG
;
Jian HU
;
Xi CAI
;
Jiansheng ZHANG
;
Weifeng SHEN
- Publication Type:Journal Article
- Keywords:
Insulin resistance;
Acute ST-elevation myocardial infarction;
Recanalizafion
- From:
Clinical Medicine of China
2009;25(5):475-477
- CountryChina
- Language:Chinese
-
Abstract:
Objective To clarify the role of insulin resistance on spontaneous recanalization of infarct-relat-ed arteries in the early phase of acute ST-elevation myocardial infarction (STEMI) in patients with normal glucose tolerance. Methods 141 consecutive patients with normal glucose tolerance and acute STEMI were enrolled in our study. Subjects were divided into TIMI 0-1 group (n =91 ) and TIMI 2-3 group (n =50) by primary coronary angi-ngraphy (CAG). The Gemini score and 0-3-vessel disease score estimated the severity and extent of coronary artery disease (CAD). Metabolic parameters and homeostasis model assessment for insulin resistance (IRI) were deter-mined. Results Serum level of fasting insulin, IRI and Gemini score were higher in TIMI 0-1 group than in TIMI 2-3 group [ (11.52±6.22)mU/L vs (7.54±3.65)mU/l,(2.79±2.32) vs (1.73±1.26),(59.17±26.95) vs ( 38.46±22.74) ( P <0.01)]. IRI was positively associated with Gemini score (r=0.185,P <0.05 ). Multivariate Logistic regression analysis revealed that IRI was independent risk factor influencing spontaneous recanalization of in-farct-related urteries(OR=2.87,95% CI=1.09-7.57,P<0.05). Conclusion Insulin resistance is independent risk factor influencing spontaneous recanalizafion of infarct-related arteries in the early phase of acute STEMI in pa-tients with normal glucose tolerance.
