Changes and significance of the contents of cholecystokinin acceptors and nitric oxide synthuse in Sphincter of Oddi and the contents of cholecystokinin and nitric oxide in the blood of patients with calculus of bile duct
10.3760/cma.j.issn.1008-6315.2009.05.030
- VernacularTitle:胆管结石患者 Oddi 括约肌中胆囊收缩素受体和一氧化氮合酶及其血中胆囊收缩素和一氧化氮水平的意义
- Author:
Kun XU
;
Xiangling MENG
;
Aman XU
;
Zhengguang WANG
- Publication Type:Journal Article
- Keywords:
Bile duct stone;
Oddi sphincter;
Nitric oxide;
Nitric oxide synthase;
Cholecystokinin;
Cholecystokinin acceptor
- From:
Clinical Medicine of China
2009;25(5):528-530
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the changes and significance of the contents of cholecystokinin (CCK) acceptors and nitric oxide synthase (NOS) in sphincter of Oddi and the contents of CCK and nitric oxide (NO) in the blood of the patients with calculus of bile duct. Methods The contents of CCK acceptors and NOS in sphincter of Oddi and the contents of CCK and NO in the blood were determined in 41 patients with gallstone and 6 controls. Results The contents of CCK and NO in the blood of patients with gallstone were significantly higher than that in control [ ( 38.91±4.85 ) pmol/L vs ( 30.67±1.81 ) pmol/L; (40.84±4.74 ) pmol/L vs ( 32.81±1.11) pmol/L] ;The contents of CCK acceptors and NOS in sphincter of Oddi in the patients with gallstone were signifi-cantly lower than in the controls [ (67.59±5.87 ) ng/L vs ( 78.99±1.71 ) ng/L; ( 457.52±45.40 ) ng/L vs ( 519.61±11.38 ) ng/L] ;The contents of CCK and NO in the blood in the different groups with calculus of bile duct were significantly different from those in the controls. Conieusion The degree of the decrease of the contents CCK acceptors and NOS in sphincter of Oddi leads to the decrease of Oddi sphincter function,resuting in cholestasis and promoting the formation of bile duct stone.
