Significance of serum cystatin-C, β2-mierogiobulin and renal hemodynamic in diagnosis of Henoch-Schoenlein purpura nephritis
10.3760/cma.j.issn.1673-4904.2009.12.008
- VernacularTitle:血清半胱氨酸蛋白酶抑制剂C、β2微球蛋白及肾血流动力学对过敏性紫癜早期肾损害的诊断价值
- Author:
Qiaowei WANG
;
Hongping WEI
;
Yaoyao WANG
- Publication Type:Journal Article
- Keywords:
Purpura,Schoenlein-Henoeh;
Cysteine proteinase inhibitors;
Beta 2-mieroglobulin;
Hemodynamic processes
- From:
Chinese Journal of Postgraduates of Medicine
2009;32(12):22-24
- CountryChina
- Language:Chinese
-
Abstract:
Objective To explore the changes and clinical significance of serum cystatin-C, β2- mieroglobulin (β2-MG) and renal hemodynamic in children with Henoch-Schoenlein purpura(HSP). Method Forty-six patients with HSP are in HSP group, 40 healthy children are in control group. Serum cystatin-C was determined by enzyme-linked immunosorbent assay, β2-MG was detected by radioimmunoassay, renal hemodynamie was detected by colour Doppler ultrasound. Results Serum cystafin-C and β2-MG in HSP group [(3.96±1.52 ), (2.74±0.82)mg/L] were higher than those in control group [(1.67±0.61), (1.89±0.47)mg/L] (P<0.01). Frequenee spectra showed high velocity and resistance, and maximum crest flow rate[(1.068±0.348) m/s] and resistance index (0.894±0.125) in systolic phase of main renal arteries were obviously higher in HSP group than those in control group [(0.859±0.357) m/s and 0.726±0.078] (P<0.05). Conclusions The level of serum cystatin-C and the change of renal hemedynamie can act as the significant indicators of early diagnosis of HSP nephritis.
