Effects of Xingding injection on the expression MCP-1 in the kidney of diabetic rats
- VernacularTitle:银杏达莫注射液对糖尿病肾病大鼠的保护作用
- Author:
Hua SHUI
;
Qua WANG
- Publication Type:Journal Article
- Keywords:
Ginkgo biloba;
Diabetic nephropathies;
Monocyte chemoattractant protein-1;
Injectio
- From:
Journal of Chinese Physician
2009;11(4):466-468
- CountryChina
- Language:Chinese
-
Abstract:
Objective To study the protective effects of Ginkgo biloba injection on the renal in diabetic nephropathy rats. Methods The models of diabetic rats were induced by streptozotecin. SD rats (n=18) were randomly divided into three groups, including control group, diabetic group and treated group. After 6 weeks, blood glucose, serum cholesterol and urinary protein were measured respectively. The expression of MCP-1 in the glomerulus was determined by immunohistechemical staining. Results Xingding injection did not influence blood glucose and serum cholesterol, but significantly inhibited expression of MCP-1 and lowered urinary protein excretion. Conclusion Xingding injection has some protective effect, which may be through down-regulating MCP-1 expression.
