Study on hypoglycemic effect of mulberry leaf powder in diabetic experimental mice
- Author:
Pham Thien Ngoc
- Publication Type:Journal Article
- Keywords:
Mulberry leaf;
Hypoglycemic effects;
Diabetic mice;
Diabetes
- MeSH:
Diabetes Mellitus , Therapeutics , Mice, Animal Experimentation
- From:Journal of Medical Research
2005;39(6):20-24
- CountryViet Nam
- Language:Vietnamese
-
Abstract:
We extracted, determined preliminary chemical compounds and antioxidant activity of mulberry leaf exttact powder in a our previous research. This continous research is on evaluation of hypoglycemic effect of mulberry leaf extract powder in experimental animals. Objectives: (1) Evaluation of hypoglycemic effect of mulberry leaf extract powder in mice after drinking starch; (2) Evaluation of hypoglycemic effect of mulberry leaf extract powder in diabetic experimental mice. Methods: evaluation of hypoglycemic effect of mulberry leaf extract powder at doses 600mg/kg and 300mg/kg in two mice experimental models: mice after drinking starch and diabetic experimental mice. Results: mulberry leaf extract powder at doses 600 mg/kg and 300 mg/kg have a hypoglycemic effect in starch drunk mice. It is best at second hour with reduces of glucocemia of 18.6 % and 9.2 % after drinking starch, respectively. Mulberry leaf extract powder at both doses of 600 mg/kg and 300 mg/kg have hypoglycemic effects at levels of 29.6 %; 18.5 % in diabetic mice injected STZ of 150 mg/kg. But mulberry leaf extract powder at both doses of 600 mg/kg and 300 mg/kg have not hypoglycemic effect in diabetic mice injected STZ of 300 mg/kg. Conclusion: Mulberry leaf extract powder at doses of 600 mg/kg, 300 mg/kg have hypoglycemic effects in starch drunk mice and diabetic mice injected STZ of 150 mg/kg.
