Effect of perhexiline injection on oxygen free radical in old patients with heart failure
10.3760/cma.j.issn.1008-6315.2009.05.009
- VernacularTitle:老年心力衰竭患者的心肌氧化损伤及冠心宁的抗氧化疗效观察
- Author:
Hong LI
;
Yuanyue ZHANG
;
Lizhong WANG
;
Hongying YANG
- Publication Type:Journal Article
- Keywords:
Heart failure;
Perhexiline;
Oxygen free radical
- From:
Clinical Medicine of China
2009;25(5):472-474
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the effect of perhexiline injection on oxygen free radical in old patients with heart failure(CHF). Methods 32 healthy parsons were taken as controls. 58 old patients with CHF were ran-domly divided into two groups. The treatment group received both basic therapy and perhexiline injection transfusion for 14 days. Malondialdehyde (MDA) ,total antioxygen capacity(TAOC) ,oxidation-low-density-lipoprotein-cholester-ol (OX-LDL-C) and superoxide dismutase(SOD) were measured before the therapy and after the therapy. Results MDA [ (5.59±1.95 )μmol/L and OX-LDL-C [ ( 808.64 ± 156.34) μg/L] were significantly higher in the old patients with CHF] than control group [ (4.04 ± 0.67 μmol/L ) and ( 538.67 ± 125.43 ) μ/L ] ( P < 0.05 ) ; SOD [ (68.69 ± 20.43 )μU/L ] and TAOC [ ( 7.72±2.13 ) kU/L ] were significantly lower in the old patients with heart failure than the matched group [(105.67±13.86 )μU/L and (9.68±1.86 ) kU/L ] ( P <0.05 ), which were posi-tively associated with CHF severity. After the improvement of the cardiac function, MDA, OX-LDL-C;SOD and TAOC recovered significantly. Conclusion The therapeutic action of perhexiline injection in old patients with CHF can re-ly on the promotion of eliminating oxygen free radical inside organism.
