Protective effects of erythropoietin against brain injury following stroke
10.3760/cma.j.issn.1673-4165.2009.04.011
- VernacularTitle:红细胞生成素对卒中后脑损伤的保护作用
- Author:
Zhangkun LUO
;
Zuoxiao LI
- Publication Type:Journal Article
- Keywords:
erythropoietin;
stroke;
brain injury;
neurorotective agents
- From:
International Journal of Cerebrovascular Diseases
2009;17(4):312-315
- CountryChina
- Language:Chinese
-
Abstract:
Erythropoietin (EPO) is a hematopoietic growth factor that has a specific role on erythroid progenitor cells. Recent studies have suggested that EPO has the important neuroprotective effect on brain damage following stroke, and its major mechanisms include neurotrophy, anti-neuronal apoptosis, inhibition of secondary inflammatory response and excitatory amino acid toxicity, maintenance of vascular integrity and promoting angiogenesis, promoting neurogenesis, as well as anti-oxidative stress.
