Granolocyte-macrophage clony-stimulating factor and neuroprotection
10.3760/cma.j.issn.1673-4165.2009.04.012
- VernacularTitle:粒细胞-巨噬细胞集落刺激因子与神经保护
- Author:
Yongjun JIANG
;
Zhiming ZHOU
;
Gelin XU
;
Xinfeng LIU
- Publication Type:Journal Article
- Keywords:
grannlocyte-macrophage colony-stimulating factor;
cerebral ischemia;
neuroprotective agents
- From:
International Journal of Cerebrovascular Diseases
2009;17(4):316-319
- CountryChina
- Language:Chinese
-
Abstract:
Granolocyte-macrophage clony-stimulating factor (GM-CSF) is a heamato-poietic growth factors involved in the generation of granulocytes and macrophages. Recent studies have suggested that the expression of GM-CSF increases following cerebral ischemia in the nervous system, indicating that GM-CSF may play an important role in the neuroprotection after ischemia. M-CSF protects neurons mainly through anti-apoptosis, promoting collateral circulation, and inhibiting energy consumption.
