Treatment of massive proteinuria in kidney transplant recipients by losartan
10.3760/cma.j.issn.0254-1785.2009.05.006
- VernacularTitle:氯沙坦治疗肾移植后大量蛋白尿
- Author:
Hua GONG
;
Mingyue TAN
;
Zhihong LIU
;
Bin SHEN
;
Yan QIN
;
Jian ZHU
;
Erdon BAO
;
Jianxing QIU
;
Yu FAN
- Publication Type:Journal Article
- Keywords:
Kidney transplantation;
Proteinuria;
Losartan
- From:
Chinese Journal of Organ Transplantation
2009;30(5):275-277
- CountryChina
- Language:Chinese
-
Abstract:
Objective To analyze the efficacy and safety of losartan in the treatment of massive proteinuria in kidney transplant recipients.Methods All of the 82 patients were randomized in two groups:losartan group and control group(amlodipine group).Both of the groups were divided into two different subsets according to blood pressure control Twenty-four-hour proteinuria,serum creatinine,blood pressure and adverse effects were observed.Results Losartan and amlodipine had the similar effects on blood pressure control The 24-h proteinuria in losartan group at the end of the study was significantly lower than that at the baseline,and there was significant difference between the losartan blood pressure control subset and the losartan blood pressure un-control subseL The effective rate and significant effective rate in losartan group for massive proteinuria were higher than in control group.Conclusion T Losartan can be effectively and safely used for the treatment of massive proteinuria in renal transplant recipients independent of blood pressure.
